Kari Nadeau

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Kari Nadeau is a physician-scientist focused on allergy and asthma treatment at Stanford University School of Medicine. She is the Naddisy Family Foundation Professor of Allergy and the Director of the Sean N Parker Center for Allergy Research at Stanford.

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Early life and family

Nadeau was born in New Hampshire, the granddaughter of immigrants from Norway and Quebec. Her mother and father were farmers in upper New York state. At 14 she wanted to be a doctor and earned money for college by delivering papers in North Plainfield, NJ, where she was raised. She played varsity basketball, track and field hockey in high school.

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Education

After graduating from Haverford College with a degree in biology, Nadeau attended Harvard Medical School via the Medical Scientist Training Program (NIH), and received a PhD in Biological Chemistry and Molecular Pharmacology and an MD in 1995. She then performed an internship and residency in pediatrics at the Children's Hospital Boston, Harvard Medical School. From 1998 to 2002, she worked in the field of biopharmaceuticals and led clinical research to obtain FDA approval for two biologics in the field of Autoimmunity and Oncology, respectively. From 2003-2006, Nadeau was a fellow in Asthma, Allergy and Immunology at the Stanford/UCSF program under Dale Umetsu. During this time, she also did a postdoctoral fellowship in human immune tolerance mechanisms in asthma and allergy.

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Academic position

In 2006, Nadeau was appointed to the Stanford University School of Medicine with appointments in Pediatrics and Otolaryngology. In 2016 she was named the Naddisy Foundation Professor of Pediatric Food Allergy, Immunology and Asthma endowed professorship under the Naddisy Family Foundation. Nadeau has served as a reviewer for NIH Study Sections, and a member of the American Lung Association Medical Board, CA. She serves on the Environmental Health Policy committee for the American Thoracic Society and is a Fellow in the American Academy of Allergy, Asthma and Immunology and is a member of ASCI (American Society of Clinical Investigation). Her laboratory focuses on the study of immunological mechanisms involved in the cause, diagnosis, and therapy for allergy and asthma. In December, 2014 Sean Parker donated $24 million to Stanford to establish the Sean N. Parker Center for Allergy Research at Stanford University, with Nadeau as the director. The center focuses on allergy research and treatment as well care for the underserved.

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Research

Nadeau's laboratory is working on scientific investigations of immune tolerance. Areas of research include:

Laboratory

1. Primary immune defects in tolerance - Gene silencing helps demonstrate the role of STAT5A and STAT5B in human immunology and signaling.,,
2. Environmental effects on tolerance - Ambient air pollution, specifically polycyclic aromatic hydrocarbons found in diesel exhaust have been demonstrated to affect FOXP3 gene expression via the aryl hydrocarbon receptor in regulatory T-cells.,
3. Immunomodulatory agents effect on tolerance - Studying the immunologic mechanisms of oral immunotherapy via the effects on Foxp3, IL-10, IFN, and IL-4.,

Clinical

The clinical research at the Sean Parker Center focuses on:

1. State of the art clinical trials that include Phase I, Phase II, Phase III, and Phase IV studies. See for Stanford Clinical trials in allergy. In addition to clinical trial research, Dr. Nadeau has been involved in the creation of international guidelines and reviews for new therapies.

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Honors and awards

• 2006 Parker B. Francis Fellow to Faculty Award
• 2006 Mary Hewitt Loveless Award in Allergy and Asthma Research
• 2007 American Academy of Allergy, Asthma, and Immunology Award for Junior Faculty
• 2007 Stanford Cardinal Free Clinics Teaching Award
• 2008 McCormick Award, Stanford University School of Medicine
• 2008 Fellow, American Academy of Allergy, Asthma and Immunology
• 2009 National Junior Faculty Award, American Lung Association
• 2010 National Junior Faculty Award, Clinical Immunological Society
• 2010 Environmental Protection Agency STAR Grant Award
• 2011 Invited speaker, National Children's Center Environment Health Summit
• 2012 Federation of Clinical Immunology Societies (FOCIS) Centers of Excellence Member
• 2013 National Adviser to the National Children's Study, NIH
• 2014 National Scientific Committee of the Immune Tolerance Network, NIH
• 2015 Elected into American Society of Clinical Investigation (ASCI)
• 2015 United Nations Annual Innovations Lecture "An Allergy Free World For Every Child"
• 2015 Faculty Fellow, Stanford Center for Innovation in Global Health
• 2015 Institute of Medicine, National Academy of Sciences (U.S.), Consultant and Panel Participant
• 2017 Environmental Protection Agency (U.S.), National Scientific Advisory Board
• 2018 Chairman, Gordon Research Conference, Food Alergy

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Media

Nadeau and her work have made a number of media appearances supporting food allergy awareness and research:

• New York Times, The Allergy Buster
• Katie Couric
• CNN, Funding a cure for food allergies
• NPR, The Doctor Trying To Solve The Mystery Of Food Allergies
• CBS This Morning, Encouraging news for food allergy sufferers
• Huffington Post,
• 60 Minutes, Allergy Free
• NBC News, Food Allergy Treatments for Children Show Promise
• Forbes, How Giving Children Foods They Are Allergic To Can Cure Them, And Other Provocative Approaches In Evolutionary Medicine
• PBS Newshour, Retraining the body to lift the life sentence of food allergies
• US News, New Hope for Kids With Multiple Food Allergies
• Stanford Scope, In Stanford clinical trial, children successfully desensitized to food allergens
• CBS Boston, HealthWatch: New Treatment To Help Kids With Multiple Food Allergies
• Allergic Living, Study Finds Combining Xolair with OIT Led to Quicker, Safer Desensitization with Multiple Food Allergens

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References

Source of the article : Wikipedia